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Prior M.J., Deng C., Weidauer D., Kuwata K., Liao J., Ye H.B., Cai Q., Zhao C., Chen L.Q., Jonikas M.C., Pilot G., Jin H., Frommer W.B. & Kim J.Y. (2024) The Arabidopsis amino acid transporter homolog UmamiT20 confers susceptibility to Botrytis cinerea. New Phytol. in revision.

Schladt T.M., Miras M., Ejike J.O., Pottier M., Xi, L., Restrepo-Escobar A., Nakamura M., Pütz N., Hänsch S., Engelhorn J., Gao C., Dickmanns M., Dalal, A., Gombos S, Lange R., Simon R., Schulze W.X., & Frommer W.B. (2024) Putative plasmodesmatal gates. Science, in review.

Arra Y., Loo E.P.I., Devanna B.N., Stiebner M. & Frommer W.B. (2024) A step-by step protocol for crossing and marker assisted breeding of Asian and African rice varieties. Bioprotocols, in review.

Engelhorn J., Snodgrass S.J., Seetharam A.S., Blank M., Schneider T., Kiwit T, Singh A., Kok A., Banf M., Khaipho-Burch M., RuncieD., Sánchez Camargo V., Stamm M., Fiorani F., Stich B., Bass H.W., Hufford M.B., Ross-Ibarra J., Frommer W.B. & Hartwig H.(2024) A maize pan-cistrome reveals that phenotypic variance is largely explained by diversity in cis-elements. bioRxiv. Nature Genetics, in review.

Loo E.P.I., Szurek B., Arra Y., Stiebner M., Buchholzer M., Vera Cruz C.M. & Frommer W.B. (2024) Sampling bias and evaluation of severity in the fight against crop diseases. Mol. Plant Microbe Interact., in revision.

Griffiths J., Rizza A., Tang B., Feng L., Frommer W.B. & Jones A.M. (2024) Gibberellin Perception Sensors 1 and 2 reveal the genesis of cellular GA dynamics necessary but not sufficient to pattern hypocotyl cell elongation. bioRxiv Plant Cell, in revision.

Schenstnyi K., Zhang Z., Liu B., Nakamura M., Schepler-Luu V., Loo E.P.I., Yang B. & Frommer W.B. (2024) Loss-of-function mutation in the polyamine transporter gene OsLAT5 as a selectable marker for genome editing. bioRxiv, Plant Methods, in revision.

Yoshinari A., Isoda I., Yagi N., Sato Y., Lindeboom J.J., Ehrhardt D.W., Frommer W.B. & Nakamura (2024) Near-infrared imaging of phytochrome-derived autofluorescence in plant nuclei. bioRxiv. Plant J. in press. doi

Loo E.P.I., Durán P, Pang TP, Westhoff P, Deng C, Durán C, Lercher M., Garido-Oter, R. & Frommer W.B. (2024) Sugar transporters spatially organize microbiota colonization along the longitudinal root axis of Arabidopsis. Sneak Peak. Cell Host Microbe 32, 543-556.e6. doi

Kim J.Y. & Frommer W.B. (2024) Phloem parenchyma. eLS 3, 1–7. doi


Loo E.P.I., Szurek B., Arra Y., Stiebner M., Buchholzer M., Vera Cruz C. M. & Frommer W.B. (2023) Sampling bias and evaluation of severity in the fight against crop diseases. Plant Disease, in revision.

Arra Y., Auguy F., Stiebner M., Chéron S., Wudick M., Miras M., Schepler-Luu V.T., Cunnac, S., Frommer W.B. & Albar F. (2023) Rice Yellow Mottle Virus resistance by genome editing of the Oryza sativa L. ssp. japonica nucleoporin gene OsCPR5.1 but not OsCPR5.2. bioRxiv. Plant Biotech J. in press.

Kim J.Y. & Frommer W.B. (2023) Phloem parenchyma. In: Encylopedia of Life Sciences, www.els.net, London: Nature Publ. Group., in press.

Ejike J., Sadoine M., Shen Y, Ishikawa Y., Sunal E., Hänsch S., Hamacher A.B., Frommer W.B., Wudick M.W., Campbell & Kleist T. (2023) A monochromatically excitable green-red dual-fluorophore fusion incorporating a new large Stokes shift fluorescent protein domain. bioRxiv. ACS Biochemistry, online. doi

Kim J.Y. & Frommer W.B. (2023) Companion cells and sieve elements. In: Encylopedia of Life Sciences, www.els.net, London: Nature Publ. Group. doi

Schepler-Luu V.T., Sciallano C., Stiebner M., Ji C., Boulard G., Diallo A., Auguy F., Char S.N., Arra Y., Schenstnyi K., Marcel Buchholzer M., Loo E.P.I., Bilaro A.L., Lihepanyama D., Mkuya M., Murori R., Oliva R., Cunnac S., Yang B., Szurek. B. & Frommer W.B. (2023) Genome editing of an African elite rice variety confers resistance against endemic and emerging Xanthomonas oryzaepv. oryzae strains. eLife, 12:e84864. doi

Gombos S., Miras M., Howe V., Lin X., Pottier M., Jazemi N.S.K., Schladt M., Ejike J., Neumann U., Hänsch S., Kuttig F., Zhang Z., Dickmanns, M., Xu P., Stefan T., Baumeister W., Frommer W.B., Simon R. & Schulze W.X. (2023) A high confidence Physcomitrium patens plasmodesmata proteome by iterative scoring and validation reveals diversification of cell wall proteins during evolution. bioRxiv. New Phytol. 238, 637-653. doi



Isoda R., Palmai Z., Chen L.Q., Tama F., Frommer W.B. & Nakamura M. (2022) Dissection of the role of sucrose and gibberellin transport activities of SWEET13 in male fertility of Arabidopsis. Proc. Natl. Acad. Sci. USA 119 (42) e2207558119. doi

Buchholzer M. & Frommer W.B. (2022) An increasing number of countries regulate genome editing in crops. New Phytol., 237, 12-15. doi

            Highlihted by Salt D., 2022. GMO or non-GMO? That is the question. New Phytol. doi

Kleist T., Lin W.I, Xu S., Maksaev G., Sadoine M., Haswell E.S., Frommer W.B. & Wudick M. (2022) OzTracs: Optical osmolality reporters engineered from mechanosensitive ion channels. Biomolecules 12, 787. doi

Wu L.B., Eom, J.S., Isoda R., Li C., Char S.N., Luo D., Luu V.T., Nakamura M., Yang B. & Frommer W.B. (2022). OsSWEET11b, a sixth leaf blight susceptibility gene involved in sugar transport-dependent male fertility. New Phytol., 234, 975–989. doi

Miras M., Pottier M., Schladt M., Ejike, J., Redzich, L., Frommer W.B. & Kim J.Y. (2022) Plasmodesmata and their role in assimilate translocation. J. Plant Physiol. 270, 153633 doi

Park J., Chavez T.M., Guistwhite J.A., Gwon S., Frommer W.B. & Cheung L.S. (2022) Development and quantitative analysis of a biosensor based on the Arabidopsis SWEET1 sugar transporter. Proc. Natl. Acad. Sci. USA 119, e2119183119. doi




Castro-Rodríguez V., Kleist T.J., Gappel N.M., Okumoto S., Machado M., Denyer T., Timmermans M.C.P., Frommer W.B. & Wudick M.M. (2021) Sponging of glutamate at the outer plasma membrane surface reveals roles for glutamate in development. Plant J. 109,664-674. doi

Kim J.Y., Loo E., Frommer W.B. & Wudick M.W. (2021) Cellular export of sugars and amino acids: Role in feeding other cells and organisms. Plant Physiol. 187, 1893–1914. doi

Moe-Lange J., Gappel N., Machado M., Wudick M.W., Sies, C.S.A., Schott-Verdugo S.N., Bonus M., Mishra S., Hartwig T., Bezrutczyk M., Basu D., Farmer E.E., Gohlke H., Malkovskiy A., Haswell E.S., Lercher M.J., Ehrhardt D.W., Frommer W.B. & Kleist T. (2021) Interdependence of a mechanosensitive anion channel and glutamate receptors in distal wound signaling. Science Adv. 7, eabg4298. doi

Schmidt S.M., Luu V.T., Buchholzer M., Arra Y. & Frommer W.B. (2021) Genome editing in the context of pathogen resistance in rice. CAB Reviews doi

Yagi N., Yoshinari A., Iwatate R., Frommer W.B. & Nakamura M. (2021) Advances in synthetic fluorescent probe labeling for live cell imaging in plants. Plant Cell Physiol. 62, 1259-1268. doi

Savadel S.D., Hartwig T., Turpin Z.M., Vera D.L., Lung P., Sui X., Frommer W.B., Dennis J.H., Zhang J. & Bass H.W. (2021) The native cistrome and sequence motif families of the maize ear. PLoS Genet. 17, e1009689. doi

Sadoine M., Ishikawa M., Kleist T., Wudick M.W., Nakamura M., Grossmann G., Frommer W.B. & Ho C.H. (2021) Designs, applications, and limitations of genetically encoded fluorescent sensors to explore plant biology. Plant Physiol. 187, 485–503. doi

Sadoine M., Reger M., Wong K.M. & Frommer W.B. (2021) Affinity series of genetically encoded high sensitivity Förster resonance energy transfer sensors for sucrose. ACS Sensors 6, 1779-1784. doi

Zöllner N., Bezrutczyk M., Reinout Laureyns & Frommer W.B. (2021) An optimized RNA in situ hybridization for monocot leaf tissue. STAR Protocols 2, 100398. doi

Prior M.J., Selvanayagam J., Kim J.G., Tomar M., Jonikas M.C., Mudgett M.B., Smeekens J., Hanson J. & Frommer W.B. (2021) Arabidopsis bZIP11 is a susceptibility factor during Pseudomonas syringae infection. bioRxiv 2020.11.25.398727. Mol Plant Microbe lnteract. 34, 439-447. doi

Isoda R., Yoshinari A., Ishikawa, Y., Sadoine M., Frommer W.B. & Nakamura M. (2021) Sensors for plant hormone quantification, localization and analysis of dynamics. Plant J. 105, 54257. doi

Wipf D., Pfister C., Mounier A., Leborgne-Castel N., Frommer W.B. & Courty P.E. (2021) Identification of putative interactors of Arabidopsis sugar transporters. Trends Plant Sci. 26, 13-22. doi

Kim J.Y, Symeonidi E., Pang T.Y., Denyer T., Weidauer D., Wudick M., Lercher M., Timmermans M. & Frommer W.B. (2021) Distinct identities of leaf phloem cells revealed by single cell transcriptomics. bioRxiv 2020.09.11.292110;doi: https://doi.org/10.1101/2020.09.11.292110; The Plant Cell 33, 511-530. doi

Highlighted by Nancy Eckhardt (2021) In Brief: Sweeter than SWEET: A Single-Cell Leaf Vasculature   Transcriptome Atlas. Plant Celldoi.org/10.1093/plcell/koaa059

Bezrutczyk M., Zöllner N., Hartwig T., Lautwein T., Köhrer K., Frommer W.B. & Kim J.Y. (2021) Evidence for a pathway for phloem loading via abaxial bundle sheath cells of maize leaves. bioRxiv 2020.09.06.284943; doi: https://doi.org/10.1101/2020.09.06.284943; The Plant Cell 33, 531-547. doi

Highlighted by Josh Strable (2021) In Brief: A Pointillist Portrait of Maize Leaf Protoplasts Points to Bundle Sheath Polarity and a Potentially New Path to Phloem Loading. Plant Cell doi

Yoshinari A., Moe-Lange J., Kleist T., Cartwright H., Quint D.A., Ehrhardt D.W., Frommer W.B.  & Nakamura M. (2021) Using Genetically Encoded Fluorescent Biosensors for Quantitative In Vivo Imaging. In: Sanchez-Serrano J.J., Salinas J. (eds.) Arabidopsis Protocols. Methods in Molecular Biology, vol 2200. Humana, New York, NY. doi


Chen H.Y., Liu Z.T, Chen I.W., Frommer W.B. & Ho C.H. (2020) Feedback inhibition of AMT1 NH4+-transporters mediated by CIPK15 kinase. bioRxiv 2020.11.03.367383; doi: https://doi.org/10.1101/2020.11.03.367383 BMC Biol. 18, 196

Yoshinari A., Moe-Lange J., Kleist T., Cartwright H., Quint D.A., Ehrhardt D.W., Frommer W.B.  & Nakamura M. (2020) Use of fluorescent biosensors in Arabidopsis. In: Arabidopsis Protocols, eds. Sanchez-Serrano JJ & Salina J., in press.

Sadoine M., Castro-Rodríguez V., Poloczek T., Javot H., Sunal E., Wudick, M. & Frommer W.B. (2020) Affinity purification of genetically encoded biosensors for quantitative analyses. Bio-protocol 10 (19): e3773.

Frommer W.B. & Itami K. (2020) The prospects of Excellence Initiatives in research. EMBO Rep. 21, e51398.

Iwatate R.J., Akira Yoshinari A., Yagi N., Ogasawara H., Grzybowski M., Kamiya M., Taki M., Yamaguchi S., Frommer W.B. & Nakamura M. (2020) Covalent self-labeling of tagged proteins with chemical fluorescent dyes in BY-2 cells and Arabidopsis seedlings. Published in BioRXiv/2020/983924. Plant Cell 32, 3081-3094. https://doi.org/10.1105/tpc.20.00439

     Highlighted by William Hughes (2020) Follow That Protein: SNAP-Tagging Permits High Resolution Protein Localization. Plant Cell tpc.00682.2020

     Highlighted by by Pavithran Narayanan (2020) SNAP ‘n’ Track: Protein localization using fluorescent dyes (Plant Cell) in Plant Science Research Weekly

Luu V.T., Stiebner M., Maldonado P.M., Valdez Gutierrez S.P., Slamet-Luedin I.H. & Frommer W.B. (2020) Protocol for efficient Agrobacterium-mediated transformation of the elite - indica rice variety Komboka. Bio-protocol 10 (17), e3739.

Wang S., Liu S., Wang J., Yokosho K., Zhou B., Yu Y.C., Liu Z., Frommer W.B., Ma J.F., Chen L.Q., Guan Y., Shou H. & Tian Z. (2020) Simultaneous changes in seed size, oil content, and protein content driven by selection of SWEET homologues during soybean domestication. Natl. Sci. Rev. nwaa110, https://doi.org/10.1093/nsr/nwaa110.

Schmidt S.M., Belisle M. & Frommer W.B. (2020) CRISPR cut to farmers’ fields. EMBO Rep., e50680



Oliva R., Ji C., Atienza-Grande G., Huguet-Tapia J.C., Pérez-Quintéro A., Li T., Eom J.S., Li C., Nguyen H., Liu B., Auguy F., Scaliano C., Luu V.T., Dossa G.S., Cunnac S., Schmidt S.M., Slamet-Loedin I.H., Vera Cruz C., Szurek B., Frommer W.B., White F.F. & Yang B. (2019) Broad-spectrum resistance to bacterial blight in rice using genome editing. Nature Biotech. 37, 1344-1350.

News & Views: Highlighted by Varshney et al. 2019 Nature Biotech 37, 1280-82

Highlighted by Nature (www.nature.com/articles/d41586-019-03284-y)

Eom J.S., Luo D., Atienza-Grande G., Yang J., Ji C., Luu V.T., Huguet-Tapia J.C., Liu B., Char S.N., Liu B., Nguyen H., Schmidt S.M., Szurek B., Vera Cruz C., White F.F., Oliva R., Yang B. & Frommer W.B. (2019) Diagnostic kit for rice blight resistance. Nature Biotech. 37, 1372-1379.

Michniewicz M., Ho C.H., Enders W.A., Gunther L.K., Powers S.K., Topp C.N., Frommer W.B. & Strader L.C. (2018) TRANSPORTER OF IBA1 links auxin and cytokinin to regulate root architecture. Dev. Cell 50, 599-609.e4.


Sosso D., Chen L.Q. & Frommer W.B. (2018) The SWEET glucoside transporter family. In: Encyl. Biophysics, (Roberts G., Ed.), Springer. online first in SpringerLink (not publically accessible yet).

Bezrutczyk M., Yang J., Eom J.S., Prior M., Sosso D., Hartwig T., Szurek B., Oliva R., Vera-Cruz C., White F.F., Yang B. & Frommer W.B. (2018) Sugar flux and signaling in plant microbe interactions. Plant J. 93, 675-685 (PMID: 29160592; DOI: 10.1111/tpj.13775).

Yang J, Luo D., Yang B., Frommer W.B. & Eom J.S. (2018) SWEET11 and 15 as key players in seed filling in rice. Published in 2017 in: www.biorxiv.org/content/early/2017/10/04/198325. New Phytol. 218, 604-615 (PMID:29393510; DOI: 10.1111/nph.15004).

Bezrutczyk M., Char S.N., Luo D.P., Liu B., Yang J., Yang B., Frommer, W.B. & Sosso D.  (2018) Impaired phloem loading in zmsweet13a,b,c sucrose transporter triple knock-out mutants in Zea mays. Published in: www.biorxiv.org/content/early/2017/10/03/197921New Phytol. 218, 594-603 (PMID:29451311; DOI: 10.1111/nph.15021).


Rizza A., Walia A., Lanquar V., Frommer W.B. & Jones A.M. (2017) Gibberellin gradients in elongating tissues stimulated by phytochrome interacting factors in hypocotyls. Nature Plants, online (ttp://rdcu.be/wnOh)(PMID:28970478).

Highlighted in News and Views | 02 October 2017 | Seeing is believing by Tamar Azoulay-Shemer, Po-Kai Hsu & Julian I. Schroeder

Ast C., Oltrogge L.M., Foret J., De Michele R. & Frommer W.B. (2017) Matryoshka, a ratiometric fluorescent protein for engineering quantitative broad range and ultra-high sensitivity biosensors. Nature Comm. 8:431 (http://rdcu.be/vAro) (PMID:28874729).

Cox Jr. K.L., Meng F., Wilkins K.E., Li F., Wang P., Booher N.J., Chen L.Q., Zheng H., Gao Q., Zheng Y., Fei Z., Yu J.Z., Isakeit T., Wheeler T., Wolf B. Frommer W.B., He P., Bogdanove & Shan L. (2017) TAL effector-mediated induction of a SWEET sugar transporter confers susceptibility to bacterial blight of cotton. Nature Comm. 169, 96-107.e12 (PMID:28537271).

Latorraca N., Fastman N., Venkatakrishnan A.J., Frommer W.B., Dror R. & Feng L. (2017) Mechanism of substrate translocation in an alternating access transporter. Cell 169, 96-107 (PMID: 28340354).


Frommer W.B.  (2016) Opinion: An Ethical Code for Conferences. The Scientist. www.the-scientist.com.

Sugiyama A., Saida Y, Yoshimizu M, Takanashi K., Sosso D., Frommer Wolf B. & Yazaki K. (2016) Molecular characterization of LjSWEET3, a sucrose transporter in nodule of Lotus japonicus.  Plant Cell Physiol., 2016 Dec 21. pii: pcw190. doi: 10.1093/pcp/pcw190. [Epub ahead of print] (PMID: 28007966).

Hu Y.B., Sosso D., Qu X.Q., Chen L.Q., Ma L., Chermak D., Zhang D.C. & Frommer W.B. (2016) Phylogenetic evidence for a fusion of archaeal and bacterial SemiSWEETs to form eukaryotic SWEETs and identification of SWEET hexose transporters in the amphibian chytrid pathogenBatrachochytrium dendrobatidisFASEB J30, 3644-3654 (PMID: 27411857)

Kryvoruchko I., Sinharoy S., Torres-Jerez I., Sosso D., Pislariu C., Guan D., Murray J., Benedito V., Frommer W.B. & Udvardi M. (2016) MtSWEET11, a nodule-specific sucrose transporter ofMedicago truncatula root nodules. Plant Physiol. 171, 554-565 (PMID: 27021190)

Ho C. & Frommer W. B. (2016). Design and functional analysis of fluorescent nitrate and peptide transporter activity sensors in yeast cultures. Bio-protocol 6(3): e1728. www.bio-protocol.org/e1728.

de Michele R., McFarlane H.E., Parsons H.T., Meents M.J., Lao J., González Fernández-Niño S., Petzold C.J., Frommer W.B., Samuels A.L. & Heazlewood J.L. (2016) Free-flow electrophoresis of plasma membrane vesicles enhances the quality of the proteome from Arabidopsis seedlings. J. Proteome Res. 15, 900-13 (PMID: 26781341).

Feng L. & Frommer W.B. (2016) Evolution of Transporters: The relationship of SWEETs, PQ-loop, and PnuC transporters. Trends Biochem. Sci. 41, 118-119 (PMID: 26749089).


White F.F. & Frommer W.B. (2015) Deciphering durable resistance one R gene at a time. Nature Genet. 47, 1376-77. (PMID: 26620111)

Sosso D., Li Q.B., Luo D., Schläpfer J., Gendrot G., Suzuki M., Koch K.E., McCarty D.R., Ross-Ibarra J., Rogowsky P., Chourey P.S., Yang B. & Frommer W.B. (2015) Seed filling in domesticated maize depends on SWEET-mediated trans-epithelial hexose transport. Nature Genet. 47, 1489-93 (PMID: 26523777)

Highlighted on DOE Office of Science homepage (http://science.energy.gov) and F1000

Provart N., Alonso J., Assmann S., Bergmann D., Brady S., Brkljacic J., Browse J., Chapple C., Colot V., Cutler S., Dangl J., Ehrhardt D., Friesner J, Frommer W.B., Grotewold E., Meyerowitz E., Nemhauser J., Nordborg M., Pikaard C., Shanklin J., Somerville C.R., Somerville S., Stitt M., Torii K., Waese J., Wagner D. & McCourt P. (2015) 50 Years of Arabidopsis research: highlights and future directions. New Phytol. 83, 1046-58 (PMID: 26465351).

Tao Y., Li S., Xu Y., Lily S. Cheung L.S., Eom J.S., Chen L.Q., Frommer W.B. & Feng L. (2015) Structure of a eukaryotic seven transmembrane SWEET transporter in a homo-trimeric complex.Nature 527, 259-63 (PMID: 26479032).

Highlighted by DOE Office of Science homepage (http://science.energy.gov), F1000 (Score 4)

Chen H.-Y., Huh J.H., Yu Y.C., Ha L.H., Chen L.C., Tholl D., Frommer W.B. & Guo W.J. (2015) The Arabidopsis vacuolar sugar transporter SWEET2 limits carbon sequestration from roots and restricts Pythium infection. Plant J. 83, 1046-58 (PMID: 26234706).

Kikuta S., Hou B.H., Sato R., Frommer W.B. & Kikawada T. (2015) FRET sensor-based quantification of intracellular trehalose in mammalian cells. Biosci. Biotech. Biochem. 27, 1-4. (PMID: 26214383)

Ast C., De Michele R., Kumke M.U. & Frommer W.B. (2015) Single-fluorophore membrane transport activity sensors with dual-emission read-out. eLife 4:e07113 (PMID: 26090909)

Frommer W.B & Feng L. (2015) Structure and function of SemiSWEET sugar transporters. Trends Biochem. Sci. 40, 480-6 (PMID: 26071195).

Eom J.S., Chen L.Q., Sosso D., Julius, B.T., Lin IW., Qu X.Q. Braun D.M. & Frommer W.B. (2015)SWEETs, transporters for intra- and intercellular sugar translocation. Curr. Opin. Plant Biol. 25, 53-62 (PMID: 25988582).

Zhou J., Peng Z, Long J., Sosso D., Liu B., Eom J.S., Huang S., Vera Cruz C., Frommer W.B.,White F.F. & Yang B. (2015) Gene targeting by the TAL effector PthXo2 reveals cryptic resistance gene for bacterial blight of rice. Plant J. 82, 632-43 (PMID: 25824104).

Chen L.Q., Lin I W., Qu XQ, Sosso D., McFarlane H.E., Londoño A., Samuels A.L. & Frommer W.B. (2015) A cascade three sequentially expressed SWEET sucrose efflux transporters in maternal tissues of the seed coat necessary for embryo nutrition. Plant Cell 27, 607-19 (PMID: 25794936).

Highlighted by F1000 (Score 6)

Rosas-Santiago P., Lagunas-Gómez D., Barkla B.J., Vera-Estrella R., Jones A., Lalonde S.,Frommer W.B., Sychrová H., Zimmermannova O. & Pantoja O. (2015) The rice cornichon (OsCNIH1) cargo receptor interacts with the sodium transporter OsHKT1;3 and targets it to the Golgi. J. Exp. Bot. 66, 2733-48 (PMID: 25750424).

Chen L.Q, Cheung L., Feng L., Tanner W. Frommer W.B. (2015) Transport of sugars. Annu. Rev. Biochem. 84, 865-94 (PMID: 25747398).

Ast C., Frommer W.B. & De Michele R. (2015) Quantification of extracellular ammonium concentrations and transporter activity in yeast using AmTrac fluorescent sensors. BioProtocols 5, 1, e1372. (www.bioprotocol.org/e1372)


Cohn M., Bart R., Shybut M., Dahlbeck D., Gomez M., Morbitzer R., Hou B.H., Frommer W.B., Lahaye T. & Staskawicz B. (2014) Xanthomonas axonopodis virulence is promoted by TAL effector-mediated induction of a SWEET sugar transporter in cassava. Mol. Plant Microbe Interact.27, 1186-98. (PMID: 25083909).

Xu Y., Tao Y, Cheung L., Fan C., Chen LQ, Xu S., Perry K., Frommer W.B. & Feng L. (2014)Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature515, 448-52. (PMID: 25186729).

Highlighted by DOE, Office of Science homepage as a Science Headline and F1000.

Denninger P., Bleckmann A., Lausser A., Vogler F., Ott T., Ehrhardt D.W., Frommer W.B., Sprunck S., Dresselhaus T. & Grossmann G. (2014) Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nature Comm. 5, 4645. (PMID: 25145880).

Highlighted by F1000

Jones A.M., Xuan Y, Xu M., Wang R.S., Ho C.H., Lalonde S., You C.H., Sardi M.I., Parsa S.A., Smith-Valle E., Pilot G., Pratelli R., Grossmann G., Acharya B.R., Hu H.C., Engineer C., Villiers F., Takeda K., Assmann S.M., Chen J., Kwak J.M., Schroeder J.I., Albert R., Rhee S.Y. & Frommer W.B. (2014) Border control - a membrane-linked interactome of Arabidopsis. Science 344, 711-16. (PMID: 24833385).

Highlighted by NSF News “Communicating with the world across the border”, released May 16, 2014; F1000

Jones A.M., Danielson J.Å.H., Manoj-Kumar S., Lanquar V., Grossmann G. & Frommer W.B.(2014) Abscisic acid dynamics in roots detected with genetically encoded FRET sensors. eLife3:e01741. (PMID: 24737862).

Highlighted by: Choi & Gilroy (2014) Plant biologists FRET over stress. eLife 2014;3:e02763. DOI: 10.7554/eLife.02763. DOI: 10.7554/eLife.01741; Williams R. (2014) Stressing and FRETing. The Scientist 28, Modus Operandi.

Ho C.H & Frommer W.B. (2014) Fluorescent sensors for activity and regulation of the nitrate transceptor CHL1/NRT1.1 and oligopeptide transporters. eLife 3, e01917. (DOI: 10.7554/eLife.01917; PMID: 24623305).

Highlighted by NSF News ‘Nitrogen-tracking tools for better crops and less pollution’, released Feb. 18, 2014

Lin I W., Sosso D., Chen L.Q., Gase K., Kim S.G., Kessler D., Klinkenberg P., Qu X.Q., Hou B.H., Carter C., Baldwin I.T. & Frommer W.B. (2014) Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9. Nature 508, 546-9. (PMID: 24670640).

Highlighted in F1000 (Score 4)

Zambon A., Zoso A., Luni C., Frommer W.B. & Elvassore N. (2014) Determination of glucose metabolic fluxes in live myoblasts by microfluidic nanosensing and data analysis. Integr. Biol. 6,277-88 (PMID: 24424957).

De Michele R. & Frommer W.B. (2014) Mitochondrial Biosensors. Int. J. Biochem. Cell Biol. 48C,39-44. (PMID: 24397954).

Hu Y., Zhang J., Jia H.G., Sosso D., Li T., Frommer W.B., Yang B., White F.F., Wang N. & Jones J.B. (2014) Lateral Organ Boundaries 1 is a disease susceptibility gene for citrus bacterial canker disease. Proc. Natl. Acad. Sci. USA 111, E521-9 (DOI:10.1073/pnas.1313271111).

Guo W.J., Nagy R., Chen S.Y., Frommer W.B. & Martinoia E. (2014) SWEET17, a facilitative fructose transporter in the tonoplast of Arabidopsis roots. Plant Physiol. 164, 777-89 (PMID: 24381066).

Lanquar V., Grossmann G., Thomine S. & Frommer W.B. (2014) Dynamic imaging of cytosolic zinc in Arabidopsis roots combining FRET sensors and RootChip technology. New Phytol. 202,198-208 (PMID: 24372442).

Highlighted in F1000 and by Michael J. Haydon, Getting a sense for zinc in plants, New Phytol. 2014, 202, 1


Xuan Y.H., Hu, Y.B., Chen L.Q., Sosso D., Ducat, D.C., Hou B.H. & Frommer W.B. (2013) Functional role of oligomerization for bacterial and plant sugar transporters of the SWEET family.Proc. Natl. Acad Sci USA 110, E3685-94.

Highlighted in F1000

De Michele R., Ast C., Loqué D., Ho C.H., Andrade S.L.A., Grossmann G., Gehne S., Kumke M.U. & Frommer W.B. (2013) Fluorescent sensors reporting the activity of ammonium transceptors in live cells. eLife 2, e00800. (Correction: Elife. 2015 Feb 18;4. doi: 10.7554/eLife.06986).

Comment by Wang & Javitch (2013) eLife 2013;2:e01029. DOI: 10.7554/eLife.01029; Highlighted by NSF News, Highlighted in F1000; Correction: Elife. 2015 Feb 18;4. DOI: 10.7554/eLife.06986

Schroeder J.I., Delhaize M., Frommer W.B., Guerinot M.L., Harrison M., Herrera-Estrella L., Horie, T., Kochian L., Munns R., Nishizawa N., Tsay Y.F. & Sanders D. (2013) Using membrane transporters to improve crops for sustainable food production. Nature 497, 60-66.

            Highlighted in F1000

Jones A., Grossmann G., Danielson, J.A.H., Sosso D., Chen L. Q., Ho, C.H. & Frommer W.B.(2013) In vivo biochemistry: Applications for small molecule biosensors in plant biology. Curr. Opin. Plant Biol. 16, 389-95.

Yuan L., Gu R., Loqué D., Frommer W.B. & von Wirén N. (2013) Allosteric regulation of transport activity by heterotrimerization of Arabidopsis ammonium transporter complexes in vivoThe Plant Cell 25, 974-84.

Bermejo C., Haerizadeh F., Sadoine M., Chermak D. & Frommer W.B. (2013) Differential regulation of glucose transport activity in yeast by specific cAMP signatures. Biochem. J452, 489-97.

Melo C.V., Okumoto S., Gomes J.R., Baptista M.S., Bahr B.A., Frommer W.B. & Duarte C.B. (2013) Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. Neuroscience 237, 66-86.

Danielson J.A.H. & Frommer W.B. (2013) Plant science. Jack of all trades, master of flowering.Science 339, 659-60.

San Marten A., Gutierrez R., Ceballo S., Ruminot I., Lerchundi R., Baeza-Lehnert F., Frommer W.B., & Barros F.L. (2013) A genetically-encoded FRET lactate biosensor shows that neurons are energized by lactate. PLoS One 8(2), e57712. DOI: 10.1371/journal.pone.0057712.

Sosso D., Chen L.Q. & Frommer W.B. (2013) The SWEET glucoside transporter family. In: Encyl. Biophysics, (Roberts G., Ed.), Springer. 5, 2556-2558.


Xue W., Ruprecht C., Street N., Hematy K., Chang C., Frommer W.B., Persson T. & Niittylä T. (2012) Paramutation-like Interaction of T-DNA loci in Arabidopsis. PLoS One 7(12), e51651. DOI:10.1371/journal.pone.0051651.

Grossmann G., Meier M., Cartwright H.N., Sosso D., Quake S.R., Ehrhardt D.W. & Frommer W.B.(2012) Time-lapse fluorescence imaging of Arabidopsis root growth with rapid manipulation of the root environment using the RootChip. J Vis Exp. 65, 4290. DOI: 10.3791/4290.

Chen J., Lalonde S., Obrdlik P., Noorani Vatani A., Parsa S.A., Vilarino C., Revuelta J.L.,Frommer W.B. & Rhee S.Y. (2012) Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Front Plant Sci. 3:124.

Funck D., Clauß K., Frommer W.B. and Hellmann H.A. (2012) The Arabidopsis CstF64-like RSR1/ESP1 protein participates in glucose signaling and flowering time control. Front. Plant Sci.3:80. DOI: 10.3389/fpls.2012.00080.

Brutnell T. & Frommer W.B. (2012) Critic at large: Food for Thought. The Scientist 6, 23-25.

Jones A.M., Ehrhardt D.W. & Frommer W.B. (2012) A never ending race for new and improved fluorescent proteins. BMC Biol. 10, 39.

De Michele R., Lalonde S., Frommer W.B. & Loqué D. (2012) Ammonium and urea transporterinventory of the Selaginella genome. Front. Plant Sci. 3, 62.

Wipf D., Loqué D., Lalonde S. & Frommer W.B. (2012) Amino acid transporter inventory of the Selaginella genome. Front. Plant Sci. 3, 36. DOI: 10.3389/fpls.2012.00036.

Pratelli R., Guerra D.D., Yu S., Wogulis M., Kraft E., Frommer W.B., Callis J. & Pilot G. (2012) The ubiquitin E3 ligase LOSS OF GDU 2 is required for GLUTAMINE DUMPER 1- induced amino secretion in Arabidopsis. Plant Physiol. 158, 1628-42.

Lalonde S. & Frommer W.B. (2012) SUT sucrose and MST monosaccharide transporter inventory of the Selaginella genome. Front. Plant Sci3, 24. DOI: 10.3389/fpls.2012.00024.

Ehrhardt D.W. & Frommer W.B. (2012) New technologies for 21st century plant science. Plant Cell24, 374-94.

Okumoto S., Jones A. & Frommer W.B. (2012) Quantitative imaging with fluorescent biosensors. Ann. Rev. Plant Biol. 63, 663-706.

Chen L.Q., Qu X.Q., Hou B.H., Osorio S., Fernie A.R. & Frommer W.B. (2012) Sucrose efflux mediated by SWEET proteins as a key step for phloem transport. Science 335, 207-211.

PERSPECTIVE: Braun D.M. (2012) SWEET! The Pathway Is Complete. Science: 335, 173-174

DOI: 10.1126/science.1216828

Highlighted in F1000 (score 11)

Frommer W.B. (2012) Genetically encoded biosensors. In: Strasburger: Textbook for Botany. Spektrum, Heidelberg


Bermejo C., Haerizadeh F., Takanaga H., Chermak D. & Frommer W.B. (2011) Optical sensors for measuring dynamic changes in steady state levels of cytosolic glucose in yeast. Nat. Prot. 6,1806–17.

Grossmann G., Guo W.J., Ehrhardt D.W., Frommer W.B., Sit R.V, Quake S.R. & Meier M. (2011) RootChip: An integrated microfluidic chip for plant science. The Plant Cell 23, 4234-40.

            Highlighted in 2013 Report of the Multinational Arabidopsis Steering Committee

Ewald J.C., Reich S., Baumann S., Frommer W.B. & Zamboni N. (2011) Engineering genetically encoded nanosensors for real-time in vivo measurements of citrate concentrations. PLoS One, 6(12), e28245.

Graff L., Obrdlik P., Yuan L., Loqué D., Frommer W.B. & von Wirén N. (2011) N-terminal cysteines affect oligomer stability of the allosterically regulated ammonium transporter LeAMT1;1. J. Exp. Bot. 62, 1361-73.

Hou B.H., Takanaga H., Chen L.Q, Qu, X.Q., Jones A., Grossmann G., Schweissgut O., Wiechert W. & Frommer W.B. (2011) Monitoring glucose flux with optical glucose sensors in mammalian cells. Nat. Prot. 6, 1818–33.

Banks J.A. et al., Frommer W.B. et al. [103 authors] (2011) The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science 332, 960-63.

Bermejo C., Ewald J., Lanquar V., Jones A. & Frommer W.B. (2011) In vivo biochemistry: quantifying ion and metabolite levels in individual cells or cultures of yeast. Biochem J. 438, 1-10.

Chaudhuri B., Hörmann F. & Frommer W.B. (2011) Dynamic imaging of glucose flux impedance using FRET sensors in wild type Arabidopsis plants. J. Exp. Bot. 62, 2411-17.


Bermejo C., Haerizadeh F., Takanaga H., Chermak D. & Frommer W.B. (2010) Dynamic analysis of cytosolic glucose and ATP levels in yeast using optical sensors. Biochem. J. 432, 399-406.

Bittner C.X., Loaiza A., Ruminot I., Larenas V., Sotelo-Hitschfeld T., Gutierrez R., Cordova A., Valdebenito A., Frommer W.B. & Barros L.F. (2010) High resolution measurement of the glycolytic rate. Frontiers Neuroenerget. 2, 26, 1-11.

Chen L.Q., Hou B.H., Lalonde S., Takanaga H., Hartung M., Qu X.Q., Guo W.J., Kim J.G., Underwood W., Chaudhuri B., Chermak D., Antony G., White F.F., Somerville S.C., Mudgett M.B. & Frommer W.B. (2010) Sugar transporters for intercellular exchange and nutrition of pathogens.Nature 468, 527-32.

News & Views: Talbot N.J. (2010) Cell biology: Raiding the sweet shop. Nature 468, 510–511.

van Ooij C. 2011 Pathogenesis: The SWEET life of pathogens. Nature Rev. Microbiol. 9, 4-5 DOI:10.1038/nrmicro2499.

Highlighted in 2011 Report of the Multinational Arabidopsis Steering Committee

Highlighted in F1000 (Score 31; third highest ranked paper in Biology all times)

Frommer W.B. (2010) Grand opportunities in physiology to address the grand challenges facing the planet. Frontiers Plant Physiol. 1,1-3.

Frommer W.B. & Sonnewald U. (2010) Progress in physiological research and its relevance for agriculture and ecology. Curr. Opin. Plant Biol. 13, 227–32.

Frommer W.B. (2010) CO2mmon sense. Science 327, 275-6.

Gutierrez R., Grossmann G., Frommer W.B. & Ehrhardt D.W. (2010) Opportunities to explore plant membrane organization with super-resolution microscopy. Plant Physiol. 154, 463-66.

Lalonde S., Sero A., Pilot G., Pratelli R., Sardi M.I., Parsa S.A., Kim D.Y., Acharya B.R., Stein E., Hu H.C., Villiers F., Takeda K., Yang Y.Z., Chen J., Chiang W., Kato N., Loqué L., Assmann S.M., Kwak J.M., Rhee S.Y., Schroeder J.I. & Frommer W.B. (2010) A small network of Arabidopsis membrane protein/ signaling protein interactions. Frontiers Physiol. 1, 24, 1-14.

Lanquar V., Loqué D. & Frommer W.B. (2010) Adjusting ammonium uptake via phosphorylation.Plant Signal. Behav. 5, 736-8.

Pratelli R., Voll L., Weber A, Frommer W.B. & Pilot G. (2010) Stimulation of non-selective amino acid efflux by a family of glutamine dumper proteins. Plant Physiol. 152, 762-73.

Takanaga H. & Frommer W.B. (2010) Facilitative plasma membrane transporters function during ER transit. FASEB J. 24, 2849-58.


Frommer W.B., Davidson M.W. & Campbell R. (2009) Genetically encoded biosensors based on engineered fluorescent proteins. Chem. Soc. Rev. 38, 2833-41.

Hou B.H., Takanaga H., Griesbeck O. & Frommer W.B. (2009) Osmotic induction of calcium accumulation in human embryonic kidney cells detected with a high sensitivity FRET calcium sensor. Cell Calcium 46, 130-35.

Lalonde S. & Frommer W.B. (2009) Mendel’s bequest gives insights into regulation of sugar supply to plant embryos. J. Exp. Bot. 60, 1-3.

Lanquar V, Loqué D, Hörmann F, Yuan L, Bohner A, Engelsberger WR, Lalonde S, Schulze WX, von Wirén N & Frommer W.B. (2009) Feedback inhibition of ammonium uptake by a phospho-dependent allosteric mechanism in Arabidopsis. The Plant Cell 21, 3610-22.

            Highlighted in F1000

Loqué D., Morac S.I., Andrade S.L.A., Pantoja O. & Frommer W.B. (2009) Pore mutations in the ammonium transporter AMT1 with increased electrogenic ammonium transport activity. J. Biol. Chem. 284, 24988-95.

            Highlighted in F1000

Murphy A., Schulz B. & Frommer W.B. (2009) Evaluating the function of putative hormone transporters. Plant Signal. Behav. 4, 147-48.

Niittylae T., Chaudhuri B., Sauer U. & Frommer W.B. (2009) Comparison of quantitative metabolite imaging tools and carbon-13 techniques for fluxomics. Methods Mol. Biol. 553, 355-72.


Blanch H.W., Adams P.D., Andrews-Cramer K.M., Frommer W.B., Simmons B.A. & Keasling J.D. (2008) Addressing the need for alternative transportation fuels: The Joint BioEnergy Institute (JBEI). ACS Chem Bio. 3, 17-20.

Cedzich A., Stransky H., Schulz B., & Frommer W. B. (2008) Characterization of cytokinin and adenine transport in Arabidopsis cell cultures. Plant Physiol. 148, 1857-67.

Chaudhuri, Hörmann F., Lalonde S., Brady S., Orlando D., Benfey P. & Frommer W.B. (2008) Protonophore- and pH-insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips. Plant J. 56, 948-62.

Dulla C., Tani H., Okumoto S., Reimer R., Frommer, W.B. & Huguenard J. (2008) Imaging of glutamate in brain slices using FRET sensors. J. Neurosci. Meth. 168, 306-19.

Grossmann G., Malinsky J., Stahlschmidt W., Loibl M., Weig-Meckl I., Frommer W.B., Opekarova M. & Tanner W. (2008) Plasma membrane microdomains regulate turnover of transport proteins in yeast. J. Cell Biol. 183, 1075-88.

            Highlighted in F1000

Kaper T., Lager I., Looger L.L., Chermak D. & Frommer W.B. (2008) FRET sensors for quantitative monitoring of pentose and disaccharide accumulation in bacteria. Biotechnol. Biofuels1, 11.

Lalonde S., Ehrhardt D.W., Loqué D., Chen J., Rhee S.Y. & Frommer W.B. (2008) Molecular and cellular approaches for the detection of protein/protein interactions and generation of large-scale protein interaction maps: Latest techniques and current limitations. Plant J. 53, 610–35.

Okumoto S., Takanaga H. & Frommer W.B. (2008) Tansley review: Quantitative imaging for discovery and assembly of the metabo-regulome. New Phytol. 180, 271-295.

Sun H., Scharff-Poulsen, A.M., Gu H., Jakobsen I., Kossmann J., Frommer W.B. & Almdal K. (2008) Phosphate sensing by fluorescent reporter proteins embedded in polyacrylamide nanoparticles. ACS Nano 2, 19-24.

Takanaga H., Chaudhuri B. & Frommer W.B. (2008) GLUT1 and GLUT9 as the major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor. Biochim. Biophys. Acta 1778, 1091-99.

Weise A., Lalonde S., Kühn C., Frommer W.B. & Ward. J.W. (2008) Introns control expression of sucrose transporter LeSUT1 in trichomes, companion cells and in guard cells. Plant Mol. Biol. 68,251-62.

Highlighted in F1000



Chaudhuri B., Niittylä T., Hörmann F. & Frommer W.B. (2007) Fluxomics with ratiometric metabolite dyes. Plant Signal. Behav. 2, 120-22.

Hörmann F., Chauduri B., Deuschle K., Lager I., Okumoto S., Lalonde, S. & Frommer, W.B. (2007) Carb fluxomics in plants. Photosynthesis Res. 91, 258.

Kaper T., Looger L.L., Takanaga H., Platten M., Steinman L. & Frommer W.B. (2007) Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle. PloS Biol. 5, e257.

            Highlighted in F1000

Loqué D., Lalonde S., Looger L.L., von Wirén N. & Frommer W.B. (2007) A cytosolic trans-activation domain essential for ammonium uptake. Nature 446, 195-98.

            Highlighted in F1000

Niittylä T., Fuglsang A.T., Palmgren M.G., Frommer W.B. & Schulze W.X. (2007) Temporal analysis of sucrose-induced phosphorylation changes in plasma membrane proteins of Arabidopsis. Mol. Cell. Proteomics 6, 1711-26.

Wiechert W., Schweissgut O., Takanaga H. & Frommer W.B. (2007) Fluxomics: mass spectrometry versus quantitative imaging. Curr. Opin. Plant Biol. 10, 323-30.

Yuan L., Loqué D., Ye F., Frommer W.B. & von Wirén N. (2007) Nitrogen-dependent posttranscriptional regulation of the ammonium transporter AtAMT1;1. Plant Physiol. 143, 732-44.


Benjdia M., Rikirsch E., Müller T., Morel M., Corratgé C., Zimmermann S., Chalot M., Frommer W.B. & Wipf D. (2006) Peptide uptake in the ectomycorrhizal fungus Hebeloma cylindrosporum: Characterization of two di- and tri-peptide transporters (HcPTR2A and B). New Phytol. 170, 401-10.

Deuschle K., Chaudhuri B., Okumoto S., Lager I., Lalonde S. & Frommer W.B. (2006). Rapid metabolism of glucose detected with FRET glucose nanosensors in epidermal cells and intact roots of Arabidopsis RNA silencing mutants. The Plant Cell 18, 2314-25.

            Highlighted in F1000

Froissard M., Belgareh-Touzé N., Buisson N., Desimone M., Frommer W.B. & Haguenauer-Tsapis R. (2006) Heterologous expression of a plant uracil transporter in yeast: Improvement of plasma membrane targeting in mutants of the Rsp5p ubiquitin protein ligase. Biotechnol. J. 1, 308–20.

Gu H., Lalonde S., Okumoto S., Looger L.L., Scharff-Poulsen A.M., Grossman A., Kossmann J., Jakobsen I. & Frommer W.B. (2006) A novel analytical method for in vivo phosphate tracking. FEBS Lett. 580, 5885-93.

Hirner A., Ladwig F., Stransky H., Okumoto S., Keinath M., Harms A., Frommer W.B. & Koch W. (2006) Arabidopsis LHT1 is a high-affinity transporter for cellular amino acid uptake in both root epidermis and leaf mesophyll. The Plant Cell 18, 1931-46.

Lager I., Looger L.L., Hilpert M., Lalonde S. & Frommer W.B. (2006) Conversion of a putative Agrobacterium sugar-binding protein into a FRET sensor with high selectivity for sucrose. J. Biol. Chem. 281, 30875-83.

Looger L.L. & Frommer W.B. (2006) High-content metabolic imaging. Screening: Trends in Drug Discovery 7, 32-33. (reprinted also in Imaging & Microscopy)

Müller T., Benjdia M., Aviolo M., Voigt B., Menzel D., Pardo A., Frommer W.B. & Wipf D. (2006) Functional expression of the green fluorescent protein in the ectomycorrhizal model fungus Hebeloma cylindrosporum. Mycorrhiza 16, 437-42.

Schmidt A., Baumann N., Schwarzkopf A., Frommer W.B. & Desimone M. (2006) Comparative studies on ureide permeases in Arabidopsis thaliana and analysis of two alternative splice variants of AtUPS5. Planta 224, 1329-40.

Wagner S., Drewke C., Leuendorf, J.E., Lytovchenko A., Bernhardt A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R. & Hellmann H. (2006) Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis. The Plant Cell 18, 1722-35.


Desimone M., Kunze R., Flügge U.I. & Frommer W.B. (2005) Plant transporters. In: Functional Plant Genomics (Leister D., ed.) Haworth Press, Binghamton, New York.

Deuschle K., Fehr M., Okumoto S., Hilpert M., Lager I., Lalonde S., Looger L.L., Persson J., Schmidt A. & Frommer W.B. (2005) Genetically encoded sensors for metabolites. Cytometry 64A, 3-9.

Deuschle K., Okumoto S., Fehr M., Looger L.L., Kozhukh, L. & Frommer W.B. (2005) Construction and optimization of a family of genetically encoded metabolite sensors by semi-rational protein engineering. Protein Sci. 14, 2304-14.

Fehr M., Deuschle K., Okumoto S., Deuschle K., Lager I., Looger L.L., Persson J., Kozhukh L., Lalonde, L. & Frommer W.B. (2005) Development and use of fluorescent nanosensors for metabolite imaging in living cells. Biochem. Soc. Trans. 33, 287-90.

Fehr M., Takanaga H., Ehrhardt D.W. & Frommer W.B. (2005) Evidence for high-capacity bidirectional glucose transport across the endoplasmic reticulum membrane by genetically encoded fluorescence resonance energy transfer nanosensors. Mol. Cell Biol. 25, 11102-12.

Lalonde S., Ehrhardt D.W. & Frommer W.B. (2005) Shining light on signaling and metabolic networks by genetically encoded biosensors. Curr. Opin. Plant Sci. 8, 1-8.

Looger L.L., Lalonde S. & Frommer W.B. (2005) Genetically encoded FRET sensors for visualizing metabolites with sub-cellular resolution in living cells. Plant Physiol. 138, 555-57.

Okumoto S., Looger L.L., Micheva K.D., Reimer R.J., Smith S.J & Frommer W.B. (2005) Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proc. Natl. Acad. Sci. USA 102, 8740-45.


Deuschle K., Funck D., Forlani G., Stransky H., Biehl A., Leister D., van der Graaf E., Kunze R. & Frommer W.B. (2004) The role of Δ1-pyrroline-5-carboxylate dehydrogenase in proline degradation. The Plant Cell 16, 3413-25.

Fehr M., Ehrhardt D.W., Lalonde S. & Frommer W.B. (2004) Live imaging of glucose homeostasis in nuclei of COS-7 cells. J. Fluores. 14, 603-09.

Fehr M., Ehrhardt D.W., Lalonde S. & Frommer W.B. (2004) Minimally invasive dynamic imaging of ions and metabolites in living cells. Curr. Opin. Plant Biol. 7, 345-51.

Frommer W.B., Fehr, M., Lalonde S. & Lager I. (2004) Metabolite imaging using FRET-based nanosensors. Cytometry A, 59A, 84.

Lalonde S., Wipf D. & Frommer W.B. (2004) Transport mechanisms for carbon and nitrogen between source and sink. Annu. Rev. Plant Biol. 55, 341-72.

Obrdlik P., El-Bakkoury M., Hamacher T., Cappellaro C., Vilarino C., Fleischer C., Ellerbrok H., Kamuzinzi R., Ledent V., Blaudez D., Sanders D., Revuelta J.L., Boles E., André A. & Frommer W.B. (2004) K+ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions. Proc. Natl. Acad. Sci. USA 101, 12242-247.

            Highlighted in F1000

Okumoto S, Deuschle K., Fehr M., Hilpert M., Lager I., Lalonde S., Looger L.L., Persson J., Schmidt A. & Frommer W.B. (2004) Genetically encoded sensors for ions and metabolites. J. Plant Nutr. Soil Sci. 50, 947-43.

Okumoto S., Koch W., Tegeder M., Fischer W.N., Biehl A., Leister D., Stierhof Y.D. & Frommer W.B. (2004) Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3. J. Exp. Bot. 55, 2155-68.

Highlighted in F1000

Pilot G., Stransky H., Bushey D.F., Pratelli R., Ludewig U., Wingate V.P.M. & Frommer W.B. (2004) Over-expression of GDU1 leads to hyper-secretion of glutamine from hydathodes of Arabidopsis leaves. The Plant Cell 16, 1827-40.

            Highlighted in F1000

Römer U., Schrader H., Günther N., Nettelstroth N., Frommer W.B. & Elling L. (2004) Expression, purification and characterization of recombinant synthase 1 from Solanum tuberosum L. for carbohydrate engineering. J. Biotechnol. 107, 135-49.

Schulz B. & Frommer W.B. (2004) A plant ABC transporter takes the lotus seat. Science 306, 622-623.

Schmidt A., Su Y.H., Kunze R., Warner S., Hewitt M., Slocum R.D., Ludewig U., Frommer W.B. & Desimone M. (2004) UPS1 and UPS2 mediate high affinity transport of uracil and 5-fluorouracil in Arabidopsis. J. Biol. Chem. 279, 44817-24.

Su Y.H., Frommer W.B. & Ludewig U. (2004) Molecular and functional characterization of a family of amino acid transporters from Arabidopsis thaliana. Plant Physiol. 136, 3104-13.


Bürkle L., Cedzich A., Döpke C., Stransky H., Okumoto S., Gillissen B., Kühn C. & Frommer W.B. (2003) Transport of cytokinins mediated by purine transporters of the PUP family expressed in phloem, hydathodes and pollen of Arabidopsis. Plant J. 34, 13-26.

Catoni E., Desimone M., Hilpert M., Wipf D., Kunze R., Schneider A., Flügge U.I., Schumacher K. & Frommer W.B. (2003) Expression pattern of a nuclear encoded mitochondrial arginine-ornithine translocator gene from Arabidopsis. BMC Plant Biol. 3, 1.

Catoni E., Schwab R., Hilpert M., Desimone M., Schwacke R., Flügge U.I., Schumacher K., & Frommer W.B. (2003) Identification of an Arabidopsis mitochondrial succinate-fumarate translocator. FEBS Lett. 534, 87-92.

Fehr M., Lalonde S., Lager I., Wolff M.W. & Frommer W.B. (2003) In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors. J. Biol. Chem. 278, 19127-33.

Highlighted in F1000

Frommer W.B. & Beachy R. (2003) Plant biotechnology. A future for plant biotechnology? Naturally! Curr. Opin. Plant Biol. 6, 147-49.

Frommer W.B., Schulze W.X. & Lalonde S. (2003) Hexokinase, Jack-of-All-Trades. Science 300, 261-63.

Klein M., Frommer W.B. & Ludewig U. (2003) Various ion channels in leaf protoplasts from the moss Physcomitrella patens. Plant Sci. 164, 657-64.

Koch W., Kwart M., Laubner M., Heineke D., Stransky H., Frommer W.B. & Tegeder M. (2003) Reduced amino acid content in transgenic potato tubers due to antisense inhibition of the leaf H+/amino acid symporter StAAP1. Plant J. 33, 211-20.

Kühn C., Hajirezaei M.R., Fernie A.R., Roessner-Tunali U., Czechowski T., Hirner B. & Frommer W.B. (2003) The sucrose transporter StSUT1 localizes to sieve elements in potato tuber phloem and influences tuber physiology and development. Plant Physiol. 131, 102-13.

            Highlighted in F1000

Lager I., Fehr M., Frommer W.B. & Lalonde S. (2003) Development of a fluorescent nanosensor for ribose. FEBS Lett. 553, 85-89.

Lalonde S., Tegeder M., Throne-Holst M., Frommer W.B. & Patrick J.W. (2003) Phloem loading and unloading of sugars and amino acids. Plant Cell Envir. 26, 37-56.

Lalonde S., Weise A., Panford Walsh R., Ward J.M. & Frommer W.B. (2003) Fusion to GFP blocks intercellular trafficking of the sucrose transporter SUT1 leading to accumulation in companion cells. BMC Plant Biology 3, 8.

Leggewie G., Kolbe A., Lemoine R., Roessner U., Lytovchenko A., Zuther E., Kehr J., Frommer W.B., Riesmeier J.W., Willmitzer L. & Fernie A.R. (2003) Overexpression of the sucrose transporter SoSUT1 in potato results in alterations in leaf carbon partitioning and in tuber metabolism but has little impact on tuber morphology. Planta 217, 158-67.

Liu L.-H., Ludewig U., Gassert B., Frommer W.B. & von Wirén N. (2003) Urea transport by nitrogen-regulated tonoplast intrinsic proteins in Arabidopsis. Plant Physiol. 133, 1220-28.

Highlighted in F1000

Liu L.H., Ludewig U., Frommer W.B. & von Wirén N. (2003) AtDUR3 encodes a new type of high-affinity urea/H+ symporter in Arabidopsis. The Plant Cell 15, 790-800.

Ludewig U., Wilken S., Wu B.H., Jost W., Obrdlik P., El Bakkoury M., Marini A.M., André B., Hamacher T., Boles E., von Wirén N. & Frommer W.B. (2003) Homo- and hetero-oligomerization of AMT1 NH4+-uniporters. J. Biol. Chem. 278, 45603–10.

Schulze W.X., Reinders A., Ward J.M., Lalonde S. & Frommer W.B. (2003) Interactions between co-expressed Arabidopsis sucrose transporters in the split-ubiquitin system. BMC Biochem. 4, 3.

Schwacke R., Schneider A., Van Der Graaff E., Fischer K., Catoni E., Desimone M., Frommer W.B., Flügge U.I. & Kunze R. (2003) ARAMEMNON – a novel database for Arabidopsis integral membrane proteins. Plant Physiol. 131, 16-26.

Wipf D., Bendjia M., Rikirsch E., Zimmermann S., Tegeder M., & Frommer W.B. (2003) An expression cDNA library for suppression cloning in yeast mutants, complementation of a yeast his4 mutant, and EST analysis from the symbiotic basidiomycete Hebeloma cylindrosporum. Genome 46, 177-81.


Becker D., Stanke R., Fendrik I., Frommer W.B., Vanderleyden J., Kaiser W.M. & Hedrich R. (2002) Expression of the NH4+-transporter gene LeAMT1;2 is induced in tomato roots upon association with N2-fixing bacteria. Planta 215, 424-29.

Desimone M., Catoni E., Ludewig U., Hilpert M., Schneider A., Kunze R., Tegeder M., Frommer W.B. & Schumacher K. (2002) A novel superfamily of transporters for allantoin and other oxo-derivatives of nitrogen heterocyclic compounds in Arabidopsis. Plant Cell 14, 847-56.

            Highlighted in F1000

Fehr M., Frommer W.B. & Lalonde S. (2002) Visualization of maltose uptake in living yeast cells by fluorescent nanosensors. Proc. Natl. Acad. Sci. USA 99, 9846-51.

Highlighted in F1000 (Score 7)

Fischer W.N., Loo D.D.F., Koch W., Ludewig U., Boorer K.J., Tegeder M., Rentsch D., Wright E.M. & Frommer W.B. (2002) Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids. Plant J. 29, 717-731.

Frommer W.B. & von Wirén N. (2002) Ping-pong with boron. Nature 420, 282-83.

Horst W.J, Frommer W.B. et al., eds. (2002) Progress in Plant Nutrition. Kluwer Academic Publishers.

Kunze R., Frommer W.B. & Flügge U.I. (2002) Metabolic engineering of plants: the role of membrane transport. Metabol. Engineer. 4, 57-66.

Ludewig U. & Frommer W.B. (2002) Genes and proteins for solute transport and sensing. In: The Arabidopsis Book. (Somerville C.R. & Meyerowitz E.M., eds.) American Society of Plant Biologist, Rockville, DOI/101199/tab.0092, www.aspb.org/publications/arabidopsis/.

Ludewig U., von Wirén N. & Frommer W.B. (2002) Uniport of NH4+ by the root hair plasma membrane ammonium transporter LeAMT1;1. J. Biol. Chem. 277, 13548-55.

Okumoto S., Schmidt R., Tegeder M., Fischer W.N., Rentsch D., Frommer W.B. & Koch W. (2002) Two high affinity amino acid transporters are specifically expressed in xylem parenchyma and in developing seeds of Arabidopsis. J. Biol. Chem. 277, 45338-46.

Reinders A., Schulze W., Kühn C., Barker L., Schulz A., Ward J.M. & Frommer W.B. (2002) Protein-protein interactions between sucrose transporters of different affinities co-localized in the same enucleate sieve element. The Plant Cell 14, 1567-77.

            Highlighted in F1000 (Score 6)

Reinders A., Schulze W.X., Thaminy S., Stagljar I., Frommer W.B. & Ward J.M. (2002) Intra- and intermolecular interactions in sucrose transporters at the plasma membrane detected by the split-ubiquitin system and functional assays. Structure 10, 763-72.

Highlighted in F1000

Rosche E., Blackmore D., Tegeder M., Richardson T., Schroeder H., Higgins T.J., Frommer W.B., Offler C.E. & Patrick J.W. (2002) Seed specific overexpression of a potato sucrose transporter increases sucrose uptake and growth rates of developing pea cotyledons. Plant J. 30, 165-75.

Schaaf G., Catoni E., Fitz M., Schwacke R., Schneider A., von Wirén N. & Frommer W.B. (2002) A putative role of the vacuolar calcium/manganese proton antiporter AtCAX2 in heavy metal detoxification. Plant Biol. 4, 612-18.

Wipf D., Bendjia M., Tegeder M. & Frommer W.B. (2002) Characterization of a general amino acid permease from Hebeloma cylindrosporum. FEBS Lett. 528, 119-24.

Wipf D., Ludewig U., Tegeder M., Rentsch D., Koch W. & Frommer W.B. (2002) Conservation of amino acid transporters in fungi, plants and animals. Trends Biochem. Sci. 27, 139-47.


Deuschle K., Funck D., Hellmann H., Däschner K., Binder S. & Frommer W.B. (2001) A nuclear gene encoding mitochondrial Δ1-pyrroline-5-carboxylate dehydrogenase and its potential role in protection from proline toxicity. Plant J. 27, 345-55.

Delrot S., Rochat C., Tegeder M. & Frommer W.B. (2001) Amino acid transport. In: Plant Nitrogen (Lea, P. & Morot-Gaudry, J.F. eds.) Springer, pp. 213-35.

Lalonde S., Franceschi V.R. & Frommer W.B. (2001) Companion cells. In: Encylopedia of Life Sciences, www.els.net, London: Nature Publ. Group.

Ludewig U., von Wirén N., Rentsch D. & Frommer W.B. (2001) Rhesus factors and ammonium: a function in efflux? Genome Biol. 2, 1010.1-1010.5.

Wilken S., Walch-Liu P., Jost W., Borel I., Frommer W.B. & von Wirén N. (2001) Regulatory levels of ammonium transport in response to varied N nutrition in tomato. In: Plant nutrition – Food security and sustainability of agro-ecosystems (Horst W.J. et al., eds.) Kluwer Academic Publishers, pp. 24-25.


Barker L., Kühn C., Weise A., Schulz B., Gebhardt C., Hirner B., Hellmann H., Schulze W., Ward J.M. & Frommer W.B. (2000) SUT2, a putative sucrose sensor in sieve elements. Plant Cell 12, 1153-64.

Gillissen B., Bürkle L., André B., Kühn C., Rentsch D., Brandl B. & Frommer W.B. (2000) A new family of high-affinity transporters for adenine, cytosine and purine derivatives in Arabidopsis. Plant Cell 12, 291-300.

Hellmann H., Barker L., Funck D. & Frommer W.B. (2000) The regulation of assimilate allocation and transport. Austr. J. Plant Physiol. 27, 583-94.

Hellmann H., Funck D., Rentsch D. & Frommer W.B. (2000) Hypersensitivity of an Arabidopsis sugar signaling mutant towards exogenous proline application. Plant Physiol. 123, 777-90.

Marini A.M., Springael J.Y., Frommer W.B. & André B. (2000) Cross-talk between ammonium transporters in yeast and interference by the soybean SAT1 protein. Mol. Microbiol. 35, 378-85.

Ono F., Frommer W.B. & von Wirén N. (2000) Coordinated diurnal regulation of low- and high-affinity nitrate transporters in tomato. Plant Biol. 2, 17-23.

Schobert C., Lucas W.J., Franceschi V.R. & Frommer W.B. (2000) Intercellular transport and phloem loading of sucrose, oligosaccharides and amino acids. In: Photosynthesis: Physiology and Metabolism (Leegood, R.C., Sharkey, T.D., von Caemmerer, S. Eds.) (Advances in Photosynthesis 9) Kluwer Academic Publishers, Dordrecht, pp. 249-74.

Schulze W., Weise A., Frommer W.B. & Ward J.M. (2000) Function of the cytosolic N-terminus of sucrose transporter AtSUT2 in substrate affinity. FEBS Lett. 485, 189-94.

Tegeder M., Offler C.E., Frommer W.B. & Patrick J.W. (2000) Amino acid transporters are localized to transfer cells of developing Pea seeds. Plant Physiol. 122, 319-25.

von Wirén N., André B., Harling H., Gojon A., Patriarca E., Merrick M., Miller A., Reiss B. & Frommer W.B. (2000) Improving fertilizer use efficiency in agroecosystems and nutrient efficiency in plants - an essential step towards modern agriculture. In: Phytosphere´99 (de Vries, G. & Metzlaff K. eds.) Elsevier Science, pp. 225-34.

von Wirén N., Gazzarrini S., Gojon A. & Frommer W.B. (2000) The molecular physiology of ammonium uptake and retrieval. Curr. Opin. Plant Biol. 3, 254-61.

von Wirén N., Lauter F.R., Ninnemann O., Gillissen B., Walch-Liu P., Engels C., Jost W. & Frommer W.B. (2000) Differential regulation of three functional ammonium transporter genes in root hairs and by light in leaves of tomato. Plant J. 21, 167-76.

Weise A., Barker L., Kühn C., Lalonde S., Buschmann H., Frommer W.B. & Ward J.M. (2000) A new subfamily of sucrose transporters, SUT4, with low affinity/high capacity localized in enucleate sieve elements of plants. Plant Cell 12, 1345-55.


Frommer W.B. & Bohnert H.J. (1999) Physiology and metabolism - talking through membranes. Curr. Opin. Plant Biol. 2, 173-77.

Frommer W.B., Ludewig U. & Rentsch D. (1999) Taking transgenic plants with a pinch of salt. Science 285, 1222-23.

Gazzarrini S., Gojon A., Frommer W.B. & von Wiren N. (1999) Three functional transporters for constitutive, diurnally regulated, and starvation-induced uptake of ammonium into Arabidopsis roots. Plant Cell 11, 937-48.

Heineke D., Kauder F., Frommer W.B., Kühn C., Gillissen B., Ludewig F. & Sonnewald U. (1999) Application of transgenic plants in understanding responses to atmospheric change. Plant Cell Environ. 22, 623-28.

Kühn C., Barker L., Bürkle L. & Frommer W.B. (1999) An update on sucrose transport in plants. J. Exp. Bot. 50, 935-53.

Lalonde S., Boles E., Hellmann H., Barker, L., Patrick J.W., Frommer W.B. & Ward J.M. (1999) The dual function of plant sugar carriers in transport and in nutrient sensing. Plant Cell 11, 707-26.

Lemoine R., Bürkle L., Barker L., Sakr S., Kühn C., Regnacq M., Gaillard C., Delrot S. & Frommer W.B. (1999) Identification of a pollen-specific sucrose transporter-like protein NtSUT3 from tobacco. FEBS Lett. 454, 325-30.

Montamat F., Tegeder M., Frommer W.B. & Delrot S. (1999) Cloning and expression of a pod-specific amino acid transporter from broad bean. Plant Mol. Biol. 41, 259-68.

Schulze W., Frommer W.B. & Ward J.M. (1999) Transporters for ammonium, amino acids and peptides are expressed in pitchers of the carnivorous plant Nepenthes. Plant J. 17, 637-46.

Schwacke R., Grallath S., Breitkreuz K.E., Stransky E., Stransky H., Frommer W.B. & Rentsch D. (1999) LeProT1, a transporter for proline, glycine betaine, and gamma-amino butyric acid in tomato pollen. Plant Cell 11, 377-91.

Tegeder M., Wang X.D., Frommer W.B., Offler C.E. & Patrick J.W. (1999) Sucrose transport into developing seeds of Pisum sativum L. Plant J. 18, 151-62.


Bürkle L., Hibbert J.M., Quick W.P., Kühn C., Hirner B. & Frommer W.B. (1998) The H+-sucrose transporter NtSUT1 is essential for sugar export from tobacco leaves. Plant Physiol. 118, 59-68.

Fischer W.N., André B., Rentsch D., Krolkiewicz S., Tegeder M., Breitkreuz K. & Frommer W.B. (1998) Amino acid transport in plants. Trends Plant Sci. 3, 188-95.

Hirner B., Fischer W.N., Rentsch D., Kwart M. & Frommer W.B. (1998) Developmental control of H+/amino acid permease gene expression during seed development of Arabidopsis. Plant J. 14, 535-44.

Ludewig F., Sonnewald U., Kauder F., Heineke D., Geiger M., Stitt M., Müller-Röber B.T., Gillissen B., Kühn C. & Frommer W.B. (1998) The role of transient starch in acclimation to elevated atmospheric CO2. FEBS Lett. 429, 147-51.

Rentsch D., Boorer K.J. & Frommer W.B. (1998) Structure and function of plasma membrane amino acid, oligopeptide and sucrose transporters from higher plants. J. Membr. Biol. 162, 177-90.

Schulz A., Kühn C., Riesmeier J.W. & Frommer W.B. (1998) Ultrastructural effects in potato leaves due to antisense-inhibition of the sucrose transporter indicate a symplasmic pre-phloem transport of assimilates and an apoplasmic mode of phloem loading. Planta 206, 533-43.


Harrington G.N., Franceschi V.R., Offler C.E., Patrick J.W., Harper J.F., Frommer W.B., Tegeder M. & Hitz W.D. (1997) Cell-specific expression of three genes involved in plasma membrane sucrose transport in developing Vicia faba seed. Protoplasma 197, 160-73.

Harrington G.N., Nussbaumer Y., Wang X.D., Tegeder M., Franceschi V.R., Frommer W.B., Patrick J.W. & Offler C.E. (1997) Spatial and temporal expression of sucrose transport-related genes in developing cotyledons of Vicia faba. Protoplasma 200, 35-50.

Kwart M., Biederer T. & Frommer W.B. (1997) AtPPK1, a putative protein kinase from thale cress. Plant Mol. Biol. 35, 389.

Kühn C., Franceschi V., Schulz A., Lemoine R. & Frommer W.B. (1997) Macromolecular trafficking indicated by localization and turnover of sucrose transporters in enucleate sieve elements. Science 275, 1298-300.

Martin T., Hellmann H., Schmidt R., Willmitzer L. & Frommer W.B. (1997) Identification of mutants in metabolically regulated gene expression. Plant J. 11, 52-63.

Sakr S., Noubahni M., Bourbouloux A., Riesmeier J., Frommer W.B., Sauer N. & Delrot S. (1997) Cutting, ageing and expression of membrane transporters. Biochim. Biophys. Acta 1330, 207-16.

von Wirén N., Bergfeld A., Ninnemann O. & Frommer W.B. (1997) An ammonium transporter from Oryza sativa. Plant Mol. Biol. 35, 681.

von Wirén N., Gazzarrini S. & Frommer W.B. (1997) Regulation of mineral nitrogen uptake in plants. In: Plant Nutrition-for sustainable food production and environment (Ando T., Fujita K., Mae T., Matsumoto H., Mori S., Sekiya J.) Kluwer Academic Publishers, Dordrecht, pp. 41-49.

von Wirén N., Gazzarrini S. & Frommer W.B. (1997) Regulation of mineral nitrogen uptake in plants. Plant & Soil 196,191-99.

Ward J., Kühn C., Tegeder M. & Frommer W.B. (1997) Sucrose transport in higher plants. Int. Rev. Cytol. 178, 41-71.

Vess C., Frommer W.B. & Rentsch, D (1997) High affinity oligopeptide transporters in Arabidopsis and tomato. Plant Physiology 114, S: 1007


Boorer K.J., Frommer W.B., Bush D.R., Kreman M., Loo D.D.F. & Wright E.M. (1996) Kinetics and specificity of a H+/amino acid transporter from Arabidopsis thaliana. J. Biol. Chem. 271, 2213-20.

Boorer K.J., Loo, D.D.F., Frommer W.B. & Wright E.M. (1996) Transport mechanism of the cloned potato H+/sucrose transporter StSUT1. J. Biol. Chem. 271, 25139-44.

Frommer W.B., Kühn C., Hirner B., Harms K., Martin T., Riesmeier J.W. & Schulz B. (1996) Sugar transport in higher plants. In: Membranes: Specialized Functions in Plants. (Smallwood M., Knox J.P. & Bowles D.J., eds.) BIOS Sci. Publ., Oxford, pp. 319-35.

Hechenberger M., Schwappach B., Fischer W.N., Frommer W.B., Jentsch T.J. & Steinmeyer K. (1996) A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a ClC gene disruption. J. Biol. Chem. 271, 33632-38.

Herbers K., Meuwly P., Frommer W.B., Métraux J.P. & Sonnewald U. (1996) Systemic acquired resistance mediated by the ectopic expression of invertase: possible hexose sensing in the secretory pathway. Plant Cell 8, 793-803.

Kühn C., Quick W.P., Schulz A., Sonnewald U. & Frommer W.B. (1996) Companion cell-specific inhibition of the potato sucrose transporter SUT1. Plant Cell & Envir. 19, 1115-23.

Lauter F.R., Ninnemann O., Bucher M., Riesmeier J. & Frommer W.B. (1996) Preferential expression of an ammonium transporter and two putative nitrate transporters in root hairs of tomato. Proc. Natl. Acad. Sci. USA 93, 8139-44.

Lemoine R., Kühn C., Thiele N., Delrot S. & Frommer W.B. (1996) Antisense inhibition of the sucrose transporter: effects on amount of carrier and sucrose transport activity. Plant Cell & Envir. 19, 1124-31.

Overvoorde P.J., Frommer W.B. & Grimes H.D. (1996) A soybean sucrose binding protein independently mediates nonsaturable sucrose uptake in yeast. Plant Cell 8, 271-80.

Rentsch D. & Frommer W.B. (1996) Molecular approaches towards an understanding of loading and unloading of assimilates in higher plants. J. Exp. Bot. 47, 1199-204.

Rentsch D., Hirner B., Schmelzer E. & Frommer W.B. (1996) Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permease genes identified by suppression of an amino acid transport targeting mutant. Plant Cell 8, 1437-46.


Fischer W.N., Kwart M., Hummel S. & Frommer W.B. (1995) Substrate specificity and expression profile of amino acid transporters (AAPs) in Arabidopsis. J. Biol. Chem. 270, 16315-20.

Frommer W.B. & Ninnemann O. (1995) Heterologous expression of genes in bacterial, fungal, animal, and plant cells. Annu. Rev. Plant Physiol. Plant Mol. Biol. 46, 419-44.

Frommer W.B., Hummel S., Unseld M. & Ninnemann O. (1995) Seed and vascular expression of a high affinity transporter for cationic amino acids in Arabidopsis. Proc. Natl. Acad. Sci. USA 92, 12036-40.

Frommer W.B. & Sonnewald U. (1995) Molecular analysis of carbon partitioning in solanaceous species. J. Exp. Bot. 46, 587-607.

Hesse H., Frommer W.B. & Willmitzer L. (1995) An improved method for generating subtracted cDNA libraries using phage lambda vectors. Nucl. Acids Res. 23, 3355-56.

Kühn C. & Frommer W.B. (1995) A novel zinc finger protein encoded by a couch potato homologue from Solanum tuberosum enables a sucrose transport-deficient yeast strain to grow on sucrose. Mol. Gen. Genet. 247, 759-63.

Lauter F.R., Ninnemann O. & Frommer W.B. (1995) Nitrogen uptake and its regulation in plants. In: Carbon Partitioning and Source/Sink Interactions in Plants (M.A. Madore & W.J. Lucas, eds.), Current Topics in Plant Physiology: An American Society of Plant Physiologists Series, Vol. 13, Rockville, Maryland, pp. 102-16.

Rentsch D., Laloi M., Rouhara I., Schmelzer E., Delrot S. & Frommer W.B. (1995) NTR1 encodes a high affinity oligopeptide transporter in Arabidopsis. FEBS Lett. 370, 264-68.


Altmann T., Damm B., Frommer W.B., Morris P., Schweizer D., Willmitzer L. & Schmidt R. (1994) Easy determination of ploidy level in Arabidopsis by means of pollen size measurement. Plant Cell Rep. 13, 652-56.

Borgmann K., Sinha P. & Frommer W.B. (1994) Changes in the two-dimensional protein pattern and in gene expression during the sink-to-source transition of potato tubers. Plant Sci. 99, 97-108.

Frommer W.B., Kwart M., Hirner B., Fischer W.N., Hummel S. & Ninnemann O. (1994) Transporters for nitrogenous compounds in plants. Plant Mol. Biol. 26, 1651-70.

Frommer W.B., Hummel S., Lemoine R. & Delrot S. (1994) Developmental changes in the two-dimensional protein pattern of plasma membrane vesicles between sink and source leaves from sugar beet. Plant Physiol. Biochem. 32, 205-09.

Frommer W.B., Hummel S. & Rentsch D. (1994) Cloning of an Arabidopsis histidine transporting protein related to nitrate and peptide transporters. FEBS Lett. 347, 185-89.

Frommer W.B., Mielchen C. & Martin T. (1994) Metabolic control of patatin promoters from potato in transgenic tobacco and tomato plants. Plant Physiol. (Life Sci. Adv.) 13, 329-34.

Hannah, L.C., Frommer, W.B., Su, J.-C, Chourey, P. and Park, W. (1994) Sucrose synthases. Plant Mol. Biol. Rep. 12, S72.

Heineke D., Kruse A., Flügge U.I., Frommer W.B., Riesmeier J., Willmitzer L. & Heldt H.W. (1994) Effect of antisense repression of the chloroplast triose-phosphate translocator on photosynthetic metabolism in transgenic potato plants. Planta 193, 174-80.

Harms K., Wöhner R.V., Schulz B. & Frommer W.B. (1994) Isolation and characterization of P-type H+-ATPase genes from potato. Plant Mol. Biol. 26, 979-88.

Ninnemann O., Jauniaux J.C. & Frommer W.B. (1994) Identification of a high affinity ammonium transporter from plants. EMBO J. 13, 3464-71.

Riesmeier J.W., Willmitzer L. & Frommer W.B. (1994) Evidence for an essential role of the sucrose transporter in phloem loading and assimilate partitioning. EMBO J. 13, 1-7.

Sonnewald U., Lerchl J., Zrenner R. & Frommer W.B. (1994) Manipulation of sink-source relations in transgenic plants: a commissioned review. Plant Cell Environ. 17, 649-58.

Willmitzer L., Frommer W.B., Kossmann J., Müller-Röber B., Riesmeier J., Sonnewald U., Flügge U.I. & Heldt H.W. (1994) Transgenic potatoes changed in carbohydrate partitioning and allocation. In: Molecular and Cellular Biology of the Potato. (Belknap W., Vayda M.E. & Park W.D., eds.) CAB International, Wallingford, pp. 57-65.


Frommer W.B., Hummel S. & Riesmeier J.W. (1993) Expression cloning in yeast of a cDNA encoding a broad specificity amino-acid permease from Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 90, 5944-48.

Frommer W.B., Riesmeier J.W., Kwart M., Hirner B., Kühn C., Martin T., Hummel S., Fischer W.N., Harms K., Wöhner R.V., Schulz B. & Willmitzer L. (1993) The role of metabolite transporters in higher plants. IBC Satellite Meeting "Transport and role of organic carbon/nitrogen in higher plants, Atami, Japan, pp. 1-7.

Kwart M., Hirner B., Hummel S. & Frommer W.B. (1993) Differential expression of two related amino-acid transporters with differing substrate specificity in Arabidopsis thaliana. Plant J. 4, 993-1002.

Lemoine R., Gallet O., Gaillard C. & Frommer W.B. (1993) Characterization of sugar efflux from sugar beet leaf plasma membrane vesicles. Plant Physiol. Biochem. 31, 731-41.

Martin T., Frommer W.B., Salanoubat, M. & Willmitzer L. (1993) Expression of an Arabidopsis sucrose synthase gene indicates a role in metabolization of sucrose both during phloem loading and in sink organs. Plant J. 4, 367-77.

Riesmeier J.W., Flügge U.I., Schulz B., Heineke D., Heldt H.W., Willmitzer L. & Frommer W.B. (1993) Antisense repression of the chloroplast triose phosphate translocator affects carbon partitioning in transgenic potato plants. Proc. Natl. Acad. Sci. USA 90, 6160-64.

Riesmeier J.W., Hirner B. & Frommer W.B. (1993) Potato sucrose transporter expression in minor veins indicates a role in phloem loading. Plant Cell 5, 1591-98.

Schulz B., Frommer W.B., Flügge U.I., Hummel S., Fischer K. & Willmitzer L. (1993) Expression of the triose phosphate translocator gene from potato is light dependent and restricted to green tissues. Mol. Gen. Genet. 238, 357-61.


Lemoine R., Gallet O., Galliard C., Frommer W.B. & Delrot S. (1992) Plasma membrane vesicles from source and sink leaves. Plant Physiol. 100, 1150-56.

Martin T., Schmidt R., Altmann T. & Frommer W.B. (1992) Non-destructive assay systems for detection of β-glucuronidase activity in higher plants. Plant Mol. Biol. Rep. 10, 37-46.

Martin T., Wöhner R.V., Hummel S., Willmitzer L. & Frommer W.B. (1992) The GUS reporter system as a tool to study plant gene expression. In: GUS protocols: Using the GUS gene as a reporter of gene expression. (Gallagher S.R., ed.) Academic Press, San Diego, pp. 23-43.

Riesmeier J.W., Willmitzer L. & Frommer W.B. (1992) Isolation and characterization of a sucrose carrier cDNA from spinach by functional expression in yeast. EMBO J. 11, 4705-13.


Borgmann K., Sinha P., Willmitzer L. & Frommer W.B. (1991) Characterization of the sink to source transition in potato tubers. In: Recent advances in phloem transport and assimilate compartmentation. (Bonnemain J.L., Delrot S., Lucas W.J., Dainty J., eds.) Ouest editions, Nantes, pp. 248- 53.

Frommer W.B., Borgmann K., Hesse H., Hildmann T., Höfgen R., Hummel S., Köster-Töpfer M., Liu X., Martin T., Peña-Cortes H., Prat S., Rocha-Sosa M., Sanchez-Serrano J.J., Schmidt R., Sonnewald U., Stratmann M. & Willmitzer L. (1991) Patatin, a bifunctional protein involved in pathogen defense and nitrogen storage? In: Commission of the European Community, Biological Sciences (Leonard A. & Durieux L., eds.) pp. 49-56.

Frommer W.B., Martin T., Schmidt R., Hummel S. & Willmitzer L. (1991) Patatin promoters as a tool to identify sink-related signal transduction pathways. In: Recent advances in phloem transport and assimilate compartmentation. (Bonnemain J.L., Delrot S., Lucas W.J. & Dainty J., eds.) Ouest editions, Nantes, pp. 254-59.

Frommer W.B., Sonnewald U., von Schaewen A., Prat S., Sanchez-Serrano J.J., Stockhaus J. & Willmitzer L. (1991) Potato gene promoters and their applications. In: Molecular methods for potato improvement, PIC, Lima, pp. 65-71.

Kikuchi S., Liu X., Frommer W.B., Köster-Töpfer M. & Willmitzer L. (1991) Identification and structural characterization of further DNA-elements in the potato and pepper genome homologous to the transposable element-like insertion Tst1. Mol. Gen. Genet. 230, 494-98.

Liu X.-Y., Rocha-Sosa M., Hummel S., Willmitzer L. & Frommer W.B. (1991) A detailed study of the regulation and evolution of the two classes of patatin genes in Solanum tuberosum L. Plant Mol. Biol. 17, 1139-54.


Köster-Töpfer M., Frommer W.B., Rocha-Sosa M. & Willmitzer L. (1990) Presence of a transposon-like element in the promoter region of an inactive patatin gene in Solanum tuberosum L. Plant. Mol. Biol. 14, 239-47.

Liu X.J., Prat S., Willmitzer L. & Frommer W.B. (1990) Cis regulatory elements directing tuber-specific and sucrose-inducible expression of a chimeric class I patatin promoter/GUS-gene fusion. Mol. Gen. Genet. 223, 401-406.

Prat S., Frommer W.B., Höfgen R., Keil M., Koßmann J., Köster-Töpfer M., Liu X.J., Müller B., Peña-Cortes H., Rocha-Sosa M., Sanchez-Serrano J., Sonnewald U. & Willmitzer L. (1990) Gene expression during tuber development in potato plants. FEBS Lett. 268, 334-38.

Willmitzer L., Basner A., Frommer W.B., Höfgen R., Liu X., Köster M., Prat S., Rocha-Sosa M., Sonnewald U. & VanCanneyt G. (1990) Tuber-specific gene expression in transgenic potato plants. In: Genetic engineering of crop plants. (Lycett G.W. & Grierson D., eds.) Butterworths, pp. 105-14.

1987 - 1989

Köster-Töpfer M., Frommer W.B., Rocha-Sosa M., Rosahl S., Schell J. & Willmitzer L. (1989) A class II patatin promoter is under developmental control in both transgenic potato and tobacco plants. Mol. Gen. Genet. 219, 390-96.

Rocha-Sosa M., Sonnewald U., Frommer W.B., Stratmann M., Schell J. & Willmitzer L. (1989) Both developmental and metabolic signals activate the promoter of a class I patatin gene. EMBO J. 8, 23-29.

Willmitzer L., Basner A., Frommer W.B., Höfgen R., Köster M., Liu X., Mielchen C., Prat S., Recknagel C., Rocha-Sosa M., Sonnewald U., Stratmann M. & VanCanneyt G. (1989) Expression of foreign genes in potato: promoters, RNA stability and protein accumulation. Vortr. Pflanzenzüchtung 16, 423-39.

Willmitzer L., Frommer W.B., Höfgen R., Köster M., Liu X., Mielchen C., Prat S., Recknagel C., Rocha-Sosa M., Sonnewald U., Stratmann M. & VanCanneyt G. (1989) The development of gene transfer and expression systems for potato. In: Parental line breeding and selection in potato breeding. (Louwes, Toussaint & Delluert, eds.) Pudoc Wageningen, pp. 112-17.

Frommer W.B. & Starlinger P. (1988) DNase I hypersensitive sites in the 5´-region of the maize Shrunken gene in nuclei from different organs. Mol. Gen. Genet. 212, 351-59.

Frommer W.B., Franken P. & Starlinger P. (1987) Chromatin structure of the sucrose synthase gene of Zea mays. Maize News Lett. 61, 44.

Werr, W., Springer, B., Maas, C., Joos, H.J., Frommer, W.B. & Starlinger, P. (1987) Multiple transacting factors may be involved in the regulation of the SHRUNKEN gene in Zea mays L. J. Cell. Biochem. 63-63.

1982 - 1985

Werr W., Frommer W.B., Maas M. & Starlinger P. (1985) Structure of the sucrose synthase gene on chromosome 9 of Zea mays L. EMBO J. 4, 1373-80.

Kuenzi, M., Assi, F., Chmiel, A., Collins, C.H., Donikian, M., Dominguze, J.B., Financsek, L., Fogarty, L.M., Frommer, W.B., Hasko, F., Hovland, J., Houwink, E.H., Mahler, J.L., Sandkvist, A., Sargeant, K., Sloover, C. & Muijs, G.T. (1985) Safe biotechnology-general considerations. Appl. Microbiol. Biotechnol. 21, 1-6.

Courage U., Döring H.P., Frommer W.B., Kunze R., Laird A., Merckelbach A., Müller-Neumann M., Riegel J., Starlinger P., Tillmann E., Weck E., Werr W. & Yoder J. (1984) Transposable elements Ac and Ds at the shrunken, waxy and Alcohol dehydrogenase loci in Zea mays. Cold Spring Harbor Symp. Quant. Biol. 49, 329-38.

Starlinger P., Courage-Tebbe U., Döring H.P., Frommer W.B., Kunze R., Laird A., Merckelbach A., Müller-Neumannn M., Tillmann E. & Werr W. (1984) Plant transposable elements - factors in the evolution of the maize genome? Plant Genetics, UCLA 35, 251-70.

Starlinger P., Courage-Tebbe U., Döring H.P., Frommer W.B., Theres K., Tillmannn E., Weck E. & Werr W. (1984) Mutations at the Shrunken locus in maize caused by the controlling element Ds. In: Genetic manipulation: Impact on man and society. (Arber W. et al., ed.) ICSU Press Cambridge University Press, Sydney, pp. 67-75.

Werr W., Frommer W.B. & Starlinger P. (1984) Structure of the Shrunken locus on chromosome 9. Maize News Lett. 58, 56-57.

Starlinger P., Courage-Tebbe U., Döring H.P., Frommer W.B., Tillmannn E., Weck E. & Werr W. (1983) Transposable elements in plants. In: Plant molecular biology. (Goldberg R.B. ed.) Alan R. Liss Inc., New York, pp. 423-434.

Werr W., Frommer W.B. & Starlinger P. (1983) Structure of the sucrose synthase gene of sucrose synthase gene of Zea mays chromosome 9. Maize News Lett. 57, 29.

Fritz H.J., Frommer W.B., Kramer W. & Werr W. (1982) Simplified preparations of blocked 2´-deoxynucleosides as starting materials for chemical and enzymatic synthesis. In: Chemical and enzymatic synthesis of gene fragments. (Gassen H.G. & Lang A., eds.) Verlag Chemie, Weinheim, pp. 43-52.